Hazardous materials should never be handled without the necessary compliment of PPE. Although PPE may need to be more extensive for highly hazardous substances, the basic set in most labs is a lab coat, neoprene gloves, vented splash goggles, closed toed shoes and long pants. This provides cover for most of the body and helps prevent accidental contact with chemicals. All PPE should be fit-checked before use to make sure the equipment will perform properly. This is especially true with respirator masks, where a small leak could have dire consequences.